주식회사 유틸렉스

Cancer immunotherapy using tumor antigen-reactive T cells.

Choi BK, Kim SH, Kim YH, Kwon BS.

Abstract

Studies over the last 30 years have shown the promise of cancer immunotherapy using T cells. In particular, since the report by Rosenberg and colleagues in 2002 that adoptive T-cell therapy (ACT) under lymphopenic conditions substantially increased response rates in melanoma patients, ACT has become a promising immunotherapeutic route to cancer treatment. Here we provide a brief history of ACT and review the characteristics of T-cell therapeutics that are specific to this approach. Since every T-cell treatment has its own unique properties in terms of number and type of target antigens, and number of epitopes and type of T cells, we review the main strategies for designing ACT: how Ag specificity is determined, how is it standardized and the need for lymphodepletion to induce epitope spreading. We also briefly consider the next generation of ACT.

KEYWORDS:

adoptive cell therapy; lymphodepletion; standardization

Immunotherapy. 2018 Mar;10(3):235-245. doi: 10.2217/imt-2017-0130.