핵심기술
특허 / 논문
| Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes. |
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| 등록일 :2022-10-31 15:21 조회수 :204 |
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Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes.
Zhou Z, Pollok KE, Kim KK, Kim Y-J, Kwon BS Abstract The 4-1BB antigen has been recently demonstrated to be a 30 kDa inducible T-cell antigen and is expressed on the cell surface of activated splenic T cells and thymocytes. This novel T-cell antigen also associates physically with the T cell-specific protein tyrosine kinase, p56lck. We show here that the inducible T-cell antigen 4-1BB is expressed on activated intestinal intra-epithelial T lymphocytes (IEL). After activation, or in the presence of IL-2, the activated IELs showed higher levels of 4-1BB. Functional studies revealed that the activated IELs triggered with anti-4-1BB monoclonal antibody could enhance the level of IEL cytotoxicity against anti-CD3-secreting hybridoma cells. Cross-linking of anti-4-1BB antibody also enhanced the proliferation of IELs. These results suggest that the inducible antigen 4-1BB has broad biological functions which not only play a role in activated splenic T cells and thymocytes but also in the mucosal immune system. |