핵심기술
특허 / 논문
| The therapeutic potential of 4-1BB (CD137) in cancer. |
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| 등록일 :2022-11-02 15:23 조회수 :2,486 |
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The therapeutic potential of 4-1BB (CD137) in cancer.
Nam KO, Kang WJ, Kwon BS, Kim SJ, Lee HW
Abstract Techniques for modulating immune cells for cancer therapy have been widely studied. One key approach that is being clinically tested is developing tumor-destructive cell-mediated immune responses by regulating co-stimulatory molecules. 4-1BB (CD137), a member of the TNF receptor family, is expressed following activation of T and NK cells. Recently, it has been reported that DCs also express 4-1BB. Cross-linking of 4-1BB provides a potent co-stimulatory signal for lymphocytes via signal transduction pathways that modulate a number of cellular responses. One remarkable response is stimulation of anti-tumor activity in vivo and in vitro. We here review the potential role of 4-1BB in cancer immunotherapy focusing on the cellular and molecular mechanisms involved.
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