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| Therapeutic potential of anti-CD137 (4-1BB) monoclonal antibodies. |
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| 등록일 :2018-03-28 17:52 조회수 :4,616 |
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Therapeutic potential of anti-CD137 (4-1BB) monoclonal antibodies.
Vinay DS, Kwon BS.
Abstract : 4-1BB (CD137) is an important T-cell stimulating molecule. The 4-1BB mAb or its variants have shown remarkable therapeutic activity against autoimmunity, viral infections, and cancer. Antibodies to 4-1BB have recently entered clinical trials for the treatment of cancer with favorable toxicity profile. In this article, we present a review documenting the efficacy and pitfalls of 4-1BB therapy. AREAS COVERED: An extensive literature search has been made on 4-1BB, spanning two decades, and a comprehensive report is presented here highlighting the origins, biological effects, therapeutic potential, and mechanistic basis of targeting 4-1BB as well as the side effects associated with such therapy. EXPERT OPINION: Research so far indicates that 4-1BB is highly protective against various pathological conditions including cancer. However, a few important side effects of 4-1BB therapy such as liver toxicity, thrombocytopenia, anemia, and suppressive effects on certain immune competent cells should be taken into consideration before it is used for human therapy. KEYWORDS: 4-1BB; T cells; autoimmune disease; cancer; therapy
Expert Opin Ther Targets. 2016;20(3):361-73. doi: 10.1517/14728222.2016.1091448. Epub 2015 Oct 1.
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